The United States Post Office and Courthouse is a historic building in Downtown Columbus, Ohio.

The building also served as a courthouse of the United States District Court for the Southern District of Ohio from its completion in 1887 until 1934, when the court moved to the Joseph P. Kinneary United States Courthouse.

It is a three-and-a-half-story building, originally designed in the Romanesque Revival style by John T. Harris.

It was expanded to three times its original size from 1907 to 1912, in a thorough process that unified old and new portions in the High Victorian Gothic style; the architect of record was James Knox Taylor.

The building has round-arched windows topped with heavy hoodmolds, and projecting stone bands between its floors.