Incumbent Republican Senator Lisa Murkowski won re-election to a third term in office.

[3] Murkowski was re-elected with 44.4% of the vote, becoming the first person in history to win three elections to the U.S. Senate with pluralities but not majorities, having taken 48.6% in 2004 and 39.5% in 2010.

[a] This record was surpassed four years later by Ricky Dale Harrington Jr., who received 33.4% of the vote in the 2020 Arkansas Senate election, which had no Democratic candidate.

She was elected to a full term in 2004 but was defeated in the Republican primary in 2010 by Tea Party challenger Joe Miller.

[6] She ran as a write-in candidate in the general election and was re-elected to a second full term with 39.5% of the vote to Miller's 35.5% and Democratic nominee Scott McAdams' 23.5%.