Rod Grams Republican Mark Dayton Democratic (DFL) The 2000 United States Senate election in Minnesota was held on November 7, 2000, to select a U.S. senator from the state of Minnesota.

The race pitted incumbent Republican Senator Rod Grams against former Minnesota State Auditor Mark Dayton.

Dayton declined to run for reelection in 2006 and ran successfully in 2010 and 2014 for governor of Minnesota.

Upon Dayton's swearing in, Democrats held both of Minnesota's U.S. Senate seats for the first time since 1978.

As of 2024, this is the last time that a man won the Class 1 Senate seat in Minnesota.