The United States sent a delegation to compete at the 2010 Winter Paralympics in Vancouver, British Columbia, Canada.

On February 26, 2010, U.S. Paralympics nominated a team of 14 men and 10 women (plus three guides) to compete in alpine skiing.

[3] Andy Soule, a veteran of the War in Afghanistan, won the bronze medal in men's 2.4 km sitting pursuit on the opening day of the Paralympics, becoming the first American to win a biathlon medal in the either the Olympic or the Paralympic Winter Games.

Alexi Salamone, born with deformed legs due to the Chernobyl nuclear disaster and later adopted by an American family, was the leading scorer for the U.S. with four goals and eight points in five games.

[18] Mike Blabac Steve Cash Taylor Chace Jimmy Connelly Brad Emmerson Joseph Howard Tim Jones Nikko Landeros Taylor Lipsett Adam Page Josh Pauls Alexi Salamone Greg Shaw Bubba Torres Andy Yohe (captain) Head coach: Ray Maluta The U.S. team qualified for the 2010 Paralympic wheelchair curling tournament based on their performance in the 2007, 2008, and 2009 World Wheelchair Curling Championships.

A nightly two-hour show covering daily competition was broadcast from March 15–23, and on-demand replays were offered on UniversalSports.com.