[4] The United States qualified eight archers for the Rio Games following their performance at the 2015 World Archery Para Championships.

[3][6] With one pathway for qualification being one highest ranked NPCs on the UCI Para-Cycling male and female Nations Ranking Lists on 31 December 2014, the United States qualified for the 2016 Summer Paralympics in Rio, assuming they continued to meet all other eligibility requirements.

[9] United States national 7-a-side football team qualified for the Rio Paralympics at 2015 World Championships because of their seventh-place finish.

[14] The United States finished 6th after beating Argentina in one placement match 4 - 3 and losing to Ireland 4 - 1.

[15][16][17] Their roster for this tournament included Alex Hendricks, Sean Boyle, Keith Johnson, David Garza, Joshua Brunais, Bryce Boarman, Gavin Sibayan, Adam Ballou, Gregory Brigman, Mason Abbiate, Andrew Bremer, Sam Holmes, Kevin Hensley and Steven Bohlemann.

[11] Jen Armbruster's participation in Rio for the US women's national goalball team made for seven Games appearances.

With one pathway for qualification being having a top finish at the 2014 IBSA Judo World Championships, the United States earned a qualifying spot in Rio base on the performance of Dartanyon Crockett in the men's -90 kg event.

[26][27] Five judoka would eventually be named to the US squad in Rio, including returning Paralympian Dartanyon Crockett.

[6] Paracanoer Alana Nichols had previously competed at the Paralympics in alpine skiing and wheelchair basketball.

[3] One pathway for qualifying for Rio involved having a boat have top eight finish at the 2015 FISA World Rowing Championships in a medal event.

The United States qualified for the 2016 Games under this criterion in the AS Men's Single Sculls event with a fifth-place finish in a time of 04:59.510.

The United States qualified a second boat in the AS Women's Single Sculls event with an eighth-place finish in a time of 05:49.760.

[28][29] The United States qualified a third boat with a second-place finish in the LTA Mixed Coxed Four event in a time of 03:19.820.

[33][34] Dee Smith, at 64 years of age, was the oldest member of the United States delegation in Rio.

The United States earned a qualifying spot at this competition in the R4 – 10m Air Rifle Standing Mixed SH2 event as a result of McKenna Dahl.

[35][36][37] The third opportunity for direct qualification for shooters to the Rio Paralympics took place at the 2015 IPC Shooting World Cup in Sydney, Australia.

At this competition, John Joss III earned a qualifying spot for their country in the R6- Mixed 50m Rifle Prone SH1 event.

Tammy Delano earned a qualifying spot for their country at this competition in the R3 Mixed 10m Air Rifle Prone SH1 event.

American swimmers competed at the 2015 IPC Swimming World Championships as part of their Rio qualifying efforts.

Bradley Sndyer earned the United States a spot after winning gold in the Men's 100m Freestyle S11 with a time of 0:56.78.

These were Cailin Currie, Tharon Drake, Tucker Dupree, McClain Hermes, Letticia Martinez, Rebecca Meyers, Martha Reuther, Bradley Snyder and Colleen Young.

[6] The United States men's national wheelchair basketball team has qualified for the 2016 Rio Paralympics.

Brazil chose Group B, which included Iran, the United States, Great Britain, Germany and Algeria.

The United States women's national wheelchair basketball team has qualified for the 2016 Rio Paralympics.

Brazil chose Group A, which included Canada, Germany, Great Britain and Argentina.

Semifinals Gold-medal match The United States qualified two competitors in the men's single event as a result of Bipartite Commission Invitation places.

[49] Russia had qualified two player in the women's singles event, Ludmila Bubnova and Viktoriia Lvova.