The United States competed at the 2022 World Aquatics Championships in Budapest, Hungary from 18 June to 3 July.

On May 19, 2022, 16 athletes were named to the World Championships roster.

[2] Men Women Mixed On May 28, 2022, 9 athletes were named to the world championships roster.

The following is American roster in the Water polo at the 2022 World Aquatics Championships – Men's tournament.

The following is American roster in the Water polo at the 2022 World Aquatics Championships – Women's tournament.