The United States qualified for the inaugural ICC Under-19 Women's T20 World Cup automatically as they were the only ICC Associate member in the Americas region that met the Event Pathway Participation Criteria for the tournament.

[2] The inaugural Women's Under-19 World Cup was scheduled to take place in January 2021, but was postponed multiple times due to the COVID-19 pandemic.

As they were the only ICC Associate member in the Americas region that met the Event Pathway Participation Criteria, the United States qualified automatically for the tournament.

[5] The side finished bottom of the initial group stage at the tournament, and lost a subsequent play-off against Scotland.

This includes their squads for their series against the West Indies, and for the 2023 ICC Under-19 Women's T20 World Cup.