University of Pennsylvania Press has an active backlist of roughly 2,000 titles and an annual output of upward of 120 new books in a focused editorial program.

It focuses heavily on publishing works related to American history and culture, ancient, medieval, and Renaissance studies, anthropology, landscape architecture, studio arts, human rights, Jewish studies, and political science.

The press also publishes 27 peer-reviewed academic journals,[4] mostly in the humanities, and the magazine Dissent.

University of Pennsylvania Press is headquartered at 3905 Spruce Street in Philadelphia.

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