Its main campus is in Chilpancingo, with facilities in Acapulco, Taxco, Iguala, Tixtla, Ometepec, Tecpan de Galeana, Altamirano and other cities in the state.

[1] In its early years, the Literary Institute was dogged by a lack of teachers and funding; it moved to Chilpancingo upon its designation as the state capital in 1870.

The State College's programs were modeled on those of the Instituto Politécnico Nacional, where the governor had studied, and it taught various engineering, agricultural and marine degrees.

[1] Throughout the 1950s, students at the school called for the institution's name to be changed to reflect its status, proposing the moniker Universidad del Sur (University of the South).

A 1960 student strike calling for the autonomy of the university ultimately ended in a massacre claiming nearly 20 lives and the fall of the state government under Governor Raúl Caballero Aburto.

Radio Universidad Autónoma de Guerrero faced constant jamming and interference, moving frequencies and even at one point to different locations in order to solve its problems.