[4] The oldest antecedent of UASLP is a Jesuit college founded in 1624 in the city of San Luis Potosí to teach literacy, as well as secondary and high school studies.

[5] In 1825, governor Ildefonso Díaz de León was directly involved in the creation of the Colegio Guadalupano Josefino.

Opening on 2 June 1826, the college initially included academic programs in Humanities, Philosophy, Theology, and Law.

[6] Unfortunately, teachers were not always available and due to political and civil unrest there were times, especially in the 19th century, the college had to suspend classes on a temporary basis.

It also included the Civil Hospital, the San Luis Potosí Public Library, the State Meteorological Observatory, and the normal school for training teachers.