The proposal was submitted on March 25, 1995 to the Paraguayan Congress by Lorenzo Zacarías López who was the chair committee.

On June 24, 1995 a Central Coordinating Committee was conformed by departmental representatives, local authorities, educators, politicians, businessmen and professionals from the city of Encarnacion.

On November 7, 1996, the Board of Universities resolves the creation and the start up of UNI with the openings of two careers, Medicine and Electromechanical Engineering.

A cross with the heart of the first Paraguayan saint, San Roque G. de Santa Cruz, projects from the top of the arc.

Inside the arc, the great book of wisdom with a golden-yellow wheat spike which symbolizes the predominantly agricultural area.