Located in the city of Bahía Blanca, the school became the sixteenth in Argentina's national university system.

In 1947, the Nation and the province Buenos Aires signed an agreement that stated that both of them would supply the funds for the operation and maintenance of the institute.

After the studies carried out by an advisor committee appointed by the Executive Power, the creation of the Universidad Nacional del Sur was approved by decree law No.

The main university complex is located at Alem 1253, where most of the Departments and laboratories operate as well as the Central Library.

It is a large building that takes up more than a block and at the front there is a fountain with a sculpture by the artist Lola Mora.

The building located at Colon 80 originally corresponded to the headquarters of the Universidad Nacional del Sur.

At Alem 925 is the "Casa de la Cultura", a colonial mansion that was formerly the center of an important villa.