Comillas Pontifical University (Spanish: Universidad Pontificia Comillas) is a private Catholic higher education institution run by the Spanish Province of the Society of Jesus in Madrid, Spain.

The university is involved in a number of academic exchange programmes, work practice schemes and international projects with over 200 institutions of higher education in Europe, Latin America, North America and Asia.

Pope Leo XIII founded the Seminary of St. Anthony of Padua in 1890 in the town of Comillas, (Province of Santander, currently Cantabria), in response to efforts made by the Marquess of Comillas to build an institution for educating local candidates to the priesthood.

In 1904, the seminary was raised to the status of a Pontifical university when Pope Pius X granted the school the power to confer academic degrees in theology, philosophy and canon law.

In 1978 the Jesuits incorporated into the university their Madrid's higher education institution ICAI-ICADE, the resultant entity of the merger in 1960 of ICAI and ICADE, two institutes established in 1908 and 1956 respectively.