The school was founded in 1958 by a group of people who wanted to supplement the agricultural vocation of the region with scientific and technological development.

The school subsequently established itself at the national level, a legal entity with administrative autonomy and independent assets under the Ministry of Education.

Act 61 of 1963 established the Polytechnic University, whose work began in 1966 with the Assistant School of Engineering: Electrical, Mechanical and Industrial (now the Faculty of Technology).

The Faculty of Education was founded in 1967, with programs in Social science, Spanish, audiovisual communication, Mathematics and Physics.

The Graduate School of Industrial Engineering Faculty was established in 1984 with MBA programs of Economic, Financial and Operations research, Statistics.

The Faculty of Educational Sciences began offering a Specialization Program in Contemporary History of Colombia and regional development in 1995.

The Superintendency of Industry and Commerce gave the university an accreditation as a certification body to allow them to issue patent stamps.