Universidad Torcuato Di Tella was founded in 1991, with the mission of educating new generations of academic, business, social and political leaders.

The latter, a non-profit institute founded in 1958 to promote research in the scientific, cultural and artistic development of Argentina, became a leading local center for avant-garde art during the 1960s.

Gerardo della Paolera was president of Universidad Torcuato Di Tella from its foundation until 2001, when he was replaced by the economist Juan Pablo Nicolini.

The reputed sociologist and political analyst Manuel Mora y Araujo became president in 2009 and continued in that role until his resignation in May 2011 for personal reasons.

It was put up for a tender in 1998 after Obras Sanitarias de la Nación was privatized, for which the university submitted the winning bid.

The university in its entirety runs from this campus since 2013, and it has been extended twice and a green terrace was opened on its roof with views of the Rio de La Plata.

In order to cater for the continued growth of the university, plans were made to construct a new building, which would be able to house an additional 1,000 students.

The nine-floor building, with 11,646 m2 of surface space and an LEED certification, was inaugurated in March 2019 with Argentine vice-president Gabriela Michetti and the deputy mayor of Buenos Aires, Diego Santilli in attendance.

In 2022, due to the continued growth of the university, a new international architectural competition was held for the New Parque Building and a new Central Piazza.

Universidad Torcuato Di Tella has 110 regular professors, of which 98 are full-time researchers, divided into nine departments: Political scientist Natalio R. Botana, historian and economist Pablo Gerchunoff, sociologist and Peronism scholar Juan Carlos Torre, architect Jorge Liernur and historian Ezequiel Gallo are Emeritus professors.

Historian Tulio Halperín Donghi, Economist Ana María Martirena-Mantel, and Nobel Laureate Finn Kydland are honorary professors.

Given its mission, ENI has published a number of academic papers and research studies in this field such as: First Survey of Inclusive Businesses in Argentina – Entrepreneurships and Small Enterprises (2012-2013); Characterizing Emerging Markets (2012), The Service Dominant Logic: A Conceptual Foundation to Address the Underserved (2012).

The Di Tella library includes the Max Hartwell, Carlos Escudé, Christiaan Huygens and Fernando Nadra collections.