University of Paris-Seine was an association of universities and higher education institutions (ComUE)[1] located in the region of Paris, France.

Started as the Paris-Seine initiative, it was renamed to University of Paris-Seine in 2015 according to the 2013 Law on Higher Education and Research (France).

[2] The association original formed as one of the Pôle de recherche et d'enseignement supérieur (PRES) in France, organizing universities and research institutions from West of Île-de-France, covering nearly the whole spectrum of sciences (fundamental, engineering, business).

As a PRES, the association was named "Université du grand ouest parisien" and was officially created the 6th of February 2012, in the form of a établissement public de coopération scientifique (EPCS).

The members of the University of Paris-Seine as of the 2015 statute are:[2]