Club Deportivo Universitario San Francisco Xavier is a professional football team based in Sucre, Bolivia, that competes in the Bolivian Primera División.

A memorable day for the club was when the team play his first match in its history against Ciencias Económicas at Cancha del Seminario (today Complejo Deportivo Universitario).

Sucre reached the final, defeating Guabirá in the game for an aggregate result of 8–1, after winning the tournament, the club was promoted to the first tier and qualified for the 2006 Copa Sudamericana.

In the Copa Sudamericana, Sucre won for an aggregate result of 3–2 to Bolívar in the club's debut for the tournament, however Universitario was eliminated by El Nacional of Ecuador in the next round.

In 2008, the club achieved his first title in Primera División during the Torneo Apertura, finishing in the first position with 43 points, also advancing to Group 5 of the Copa Libertadores 2010.

Universitario debuted in the tournament with a home victory 2–0 in the first round, against the Chilean champion of the Libertadores 1991, Colo-Colo, with the goals of Roberto Galindo and Sacha Lima.

After of the same game, the left back of the Chilean club, Roberto Cereceda was involved in a doping controversy, with a risk a two-year ban for part of the CONMEBOL.