They have performed several popular plays and musicals throughout the years such as Into the Woods, A Man of No Importance, The Hunchback of Notre Dame, West Side Story, Les Misérables, Ragtime, Carousel, Evita, Aida, Miss Saigon, The Wiz, Beauty and the Beast, Shrek, Guys and Dolls and Sweeney Todd.

University has presented Lend Me A Tenor in the fall of 2010, and was one of the first high schools in the world to put on a production of Phantom of the Opera in the spring of 2011.

In 2011, Troupe 4848 entered Jesus Christ Superstar as their One Act in the District 5 competition, won straight superiors.

In 2019, Troupe 4848 presented Silas Marner once again, and received superiors, and an additional fan favorite award.

In 2020, Spoon River Anthology was presented, and also received superiors AND Top Honors for the Online Regional Festival.

They also participate annually in the Applause Awards at the Dr. Phillips Performing Arts Center, an award ceremony created to recognize Central Florida high schools theatrical programs, technical crew, and individual actor performances.

This upcoming school year (2021–22), the program plans on performing for their One Act, “The Miraculous Journey of Edward Tulane”, for the winter, “Romeo and Juliet” the first ever full length Shakespeare play produced by UHS, and for the spring, “Pippin”.

Recent field shows by the marching band include "One City Block" (2005), "There And Back Again" (2006), "Almost Yesterday" (2007), "The Enigma" (2008), "An Inconvenient Truth" (2009), "Through the Mind of a Child" (2010), "Reflections" (2011), "Ballet Méchanique" (2012), "Danzón Universitas" (2013), "Pandora's Box" (2014), "The Ring Cycle" (2015), "Je Suis" (2016), "Let There Be Light" (2017), "No Part Of Easy" (2018), "Out of the Silent Planet" (2019), and "The Glass Cage" (2021).

[4] An FMBC regional competition called the "University Classic" has been hosted by the band annually in October since 2004.

Sabor Latino was directed by Giovanni Nieves along with several team captains (Valerie Kerr 08–09, Julissa Henry 09–10, Frankie Agosto 10–11, Juan Medina ‘11, Kenneth Shuga ‘11).

SL performed at every Hispanic Heritage Month at the school bell tower, and also participated in many charity events.

While limited for the 2020-21 school year, the program has put out multiple concerts, and still maintained its status of excellence, with students being placed into chorus’ on the county level.