[1] In 2000, the school, along with its counterpart at the University of California, Los Angeles (UCLA), were renamed in honor of Henry Samueli, co-founder of Irvine-based Broadcom Corporation, for his 1999 donations of $20 million and $30 million to the schools of engineering at UC Irvine and UCLA, respectively.

[2][3] The most recent permanent Dean of the HSSoE was Gregory Washington, who held the position from August 1, 2011 until July 1, 2020 when he resigned in order to accept appointment as President of George Mason University.

Programs not accredited include two of the aforementioned interdisciplinary degrees (general Engineering, Networked Systems).

These research centers include:[10] Most of the school's facilities occupy one of the "spokes" of the UC Irvine campus' "Ring Road", its main 1-mile (1.6 km) circular pedestrian mall on which the university's academic schools (except for Arts, Business, and Medicine) are situated.

However, following ICS' 2002 elevation to school status, as well as its 2004 endowment from Orange County real estate mogul Donald Bren, ICS moved many of its laboratories and offices out of shared space into the newly constructed Bren Hall located between Engineering and the Physical Sciences.

Founded as the School of Engineering in 1965 with just two faculty members and 75 students declaring engineering majors; the school today serves more than 4,500 students (3,598 undergraduates and 951 graduates) enrolled in 12 undergraduate degree majors and 13 graduate degree programs.