Administered by the university's George A. Smathers Libraries system, Marston hosts the university's extensive collections in agriculture, biological sciences, chemical and physical sciences, engineering, mathematics, and statistics, as well as librarians trained to help students and faculty working in these fields.

[2] Marston was a medical doctor, research scientist and Rhodes Scholar, who previously served as the dean of the University of Mississippi School of Medicine (1961–1965) and the director of the National Institutes of Health (1968–1973).

Collaboration Commons is the name for the renovated first floor of the Marston Science Library.

Completed in the Fall of 2014, the approximately $5.7 million project was designed to act as a progressive study area for students.

[6] Innovative technology was also added, with 3D scanning and 3D printing equipment, as well as a multi-touch visualization wall and the new MADE@UF Lab for creating mobile apps and games all included as a part of the project.