Upon Dean Benedict's death in 1914, Robert Wilson became the director of the school and remained in that position until 1948.

The school's location remained in Terrell Hall until 1939 when it moved into the second and third floors of the newly remodeled New College building.

During his tenure the College received Georgia State lottery funds to increase technology in education and the Millikan Educational Resources Center was converted to a computer laboratory for student access.

Dr. Svein Øie of the University of California San Francisco became Dean on January 1, 2000.

Under his guidance, the College has increased its class size, expanded its regional presence, been involved in establishing a Center for Drug Discovery and a Center for Mass Destruction Defense, increased interdisciplinary research and strengthened its research focus.

In 2007, the Georgia Legislature approved funding of $44 million for a new 93,288 square foot addition to the school.