University of Holy Cross (UHC) is a private Catholic[4] liberal arts college in New Orleans, Louisiana.

Its original location was in the Bywater area of New Orleans.

In 1947, a 40-acre (16 ha) parcel of land in Algiers was donated to the Marianites.

In August 2011, the Marianites dismissed the college's president and all 19 of its trustees without warning.

University of Holy Cross is situated on a 16-acre (65,000 m2) campus in a middle-class residential neighborhood of the Algiers area of New Orleans on the west bank of the Mississippi River.