The first year of classes were largely virtual due to the COVID-19 pandemic with in person anatomy lab for dissections with students broken into small groups.

The inaugural class chose to name their learning communities after Dr. Thelma Patten and Dr. Rebecca Lee Crumpler, the first black female physician in the United States.

With a large emphasis on health equity and increasing diversity in the physician population as well as providing mentorship in the local areas, medical students provide mentorship to pre-medical students at Jack Yates High School, located in the Third Ward.

The journal includes both research and artistic pieces, open to submissions from health care providers and students in Texas, ISSN: 2834–4618.

In February 2021, the College of Medicine was named a member institution of the Texas Medical Center.

"The three-story, 130,000-square-foot building is being constructed on 43-acres and will feature modern classroom and meeting spaces, state-of-the-art anatomy and simulation suites, and more.