A large and varied schedule of concerts and recitals featuring students, faculty, and guest performers serves the concertgoing public of Houston throughout the year.

Ensembles at the Moores School include the Wind Ensemble (recipient of multiple Grammy nominations), the Moores School Symphony Orchestra, the Concert Chorale, AURA (a contemporary music ensemble), the Jazz Orchestra, the Mariachi Pumas,[4] the Spirit of Houston Cougar Marching Band, the Symphonic Winds, the Concert Band, the Cougar Brass, the Choral Artists, the Chamber Singers, the Concert Women's Chorus, the Houston Symphony Chorus, the University Men's Chorus, the University Women's Chorus, the Moores School Percussion Ensemble, and Collegium Musicum (early music).

The Edythe Bates Old Moores Opera Center presents productions consistently lauded as being of professional quality.

Nevertheless, Moores School graduates in significant numbers can be found on concert stages, on college faculties, and in other leading professional musical roles worldwide.

[citation needed] The Moores School hosts a number of musical activities outside the scope of its basic program of university instruction.

These include the following: In addition, the Moores School of Music is home to chapters of four collegiate music fraternities and one honor society: Located in the Arts District of the University of Houston campus, the centerpiece of the $24 million Rebecca and John J. Moores School of Music Building is the 800-seat Moores Opera House, which has a ceiling mural by Frank Stella, light fixtures by Isaac Maxwell, and a green room displaying paintings by Ary Stillman.