It was formerly called Physicians Memorial Hospital and, until recently, operated under the name Civista Medical Center.

The medical center's mission requires the organization to reinvest resources into the community by providing health education and open access to healthcare.

In 1926, a tornado cut through Charles County leaving many dead and injured.

Today, the hospital has the capacity to serve 42,000 patients annually.

[3] On July 1, 2013, the Civista Medical Center began operating under the name University of Maryland Charles Regional Medical Center in the University of Maryland Medical System, becoming the first expansion of UMMS in the Washington, DC metropolitan area.