The School also hosts professional programs for students interested in physician assistant studies, physical therapy, occupational therapy, medical laboratory science, sports medicine, and public health.

In 2020 the School announced it would be taking applications for the world's first standalone doctoral program in indigenous health.

Research is also a very important part of the UND School of Medicine and Health Sciences.

The school was founded in 1905 to provide the first two years of medical education, first offering students a Bachelor of Sciences in Medicine (BS Med) degree.

In May 2013, the 63rd Assembly of the North Dakota Legislature approved funding for a new $124 million, 325,000-square-foot, four-story building on the northeast corner of the UND campus.