[4] Perelman Quadrangle is centered around a plaza between Houston and College halls, but event spaces are located farther throughout Penn's campus.

Across the plaza is College Hall (1871), Penn's first building on its West Philadelphia and home to most classrooms and administrative space.

The Irvine building contains a grand auditorium with a substantial pipe organ given by Cyrus Curtis, and also includes several smaller performance and rehearsal spaces.

Williams Hall (1972), which houses offices and classrooms for humanities and language departments, also overlooks the plaza.

Iron Gate occupies space of the former Tabernacle Presbyterian Church and the ARCH, formerly the Christian Association, houses multiple student organizations and a cafe.