The term “DALTA” in the name of the university is the acronym for Daisy Antonio Laperal Tamayo, the conjugal founders.

The first campus established is the Perpetual Help College and Hospital in Manila to meet the local and international demand for nurses.

Two years later (1970), the Perpetual Help College and Hospital Campus was founded in Malasiqui, Pangasinan, in response to the "government's program to promote health and educational development in the rural areas".

Today, the former UPHR is known by its amended official and registered business name as University of Perpetual Help System Dalta (UPHSD).

Today, its amended official and registered business name is University of Perpetual Help DALTA Medical Center (UPHDMC).

Likewise, Richard Antonio M. Tamayo was appointed as President of the University of Perpetual DALTA Medical Center.

The CEO created the executive board which directly formulates, implements, and supervises all policies, guidelines, programs and projects relative to the philosophy, vision, mission, accreditation, standardization of curricular content and instruction, quality assurance, professional development, faculty research, and community service, among others, of the UPH Las Piñas and UPH Biñan.

The Sanlahi Pangkat Mananayaw takes its name from two coined words, Isang Lahi which literally means, One Race.

PDC in short, it is the official street/hip-hop dance team & representative of the University of Perpetual Help System Dalta - Las Piñas.

The team was formed on August 20, 2015 and PDC is Founded by Mr. Bobby John H. Salinas the Performing Arts Group Coordinator, and their current moderator, Coach Cristin Cruz Gapasin.

Students, faculty and staff members also participate in intramural and club sports, and use the excellent athletics and fitness facilities.

The University of Perpetual Help System DALTA is a member of National Collegiate Athletic Association (Philippines) since 1984 with UPHSD Altas as the team representing the school in various sports.

Since it has joined the league, the Altas basketball team had won two General Championships from their winning years 1995-1996 and 1996–1997 in two consecutive seasons.

The Junior Team, Jherald Martinez and Cristopher Soriano, placed second in their barefoot fight in the beach volleyball finals.

The program was founded by Dr./Bgen Antonio Laperal Tamayo, chairman of the board and CEO of the UPHS and former BuCor director Vicente Eduardo in 1984.

Located in Sitio Lawaan, Lumangbayan, Abra de Ilog, Occidental Mindoro, the University of Perpetual Help Learning Center Mission School provides the Mangyan indigenous people in the area with free education, inclusive of their uniforms, school supplies, learning materials, clothing and other personal necessities.

It was envisioned by Dr./Bgen Antonio Laperal Tamayo to help the Mangyan people gain an upper hand in the social ladder of life.

The school has embarked into a Functional Literacy Program last June 9, 2012 and officially received its Certificate of Recognition last September 13, 2012 from the Department of Education (DepED) of Region IV – MIMAROPA Division of Occidental Mindoro, Mamburao, thereby becoming a part of the Alternative Learning System (ALS) and Projects.