In the fall of 2020, Pitt-Titusville converted its academic programs into the University of Pittsburgh at Titusville Education and Training Hub.

This program incorporates three entities into UPT: Northern Pennsylvania Regional College (NPRC), the university's Swanson School of Engineering, and Manchester Bidwell Corporation.

The University of Pittsburgh at Titusville was established in 1963 in response to a long-recognized need for higher educational opportunities in the Oil Creek Region.

Following a successful fundraising campaign, UPT opened its doors in the fall of 1963 with classes being held in McKinney Hall.

The Titusville Campus, located on and adjacent to the former McKinney Estate, offers modern comfort and convenience in a traditional residential setting.

[10] The recently restored gazebo, now known as the Serenity House, serves as a quiet gathering place for students and as a location for special events.

The 32,000-square-foot (3,000 m2) structure houses biology, chemistry, nursing, and computer laboratories, faculty offices, plus two demonstration/lecture halls and one general classroom, all with multi-media video and smart technology systems.

In 2013, a $4.6 million, 8,100-square-foot (750 m2) addition to the McKinney Student Union was opened that houses a new dining facility that includes a Wood Stone Oven and a cutting edge service area with cook-to-order stations offering a variety of food choices.

Pitt-Titusville offers an Associate of Science in Nursing degree and various certificate and training programs through the University of Pittsburgh at Titusville Education and Training Hub, in collaboration with the Northern Pennsylvania Regional College (NPRC), https://regionalcollegepa.org/https://regionalcollegepa.org/ the University of Pittsburgh Swanson School of Engineering - Manufacturing Assistance Center (MAC), and Manchester Bidwell Corporation.