Its campus is home to the UPRH Astronomical Observatory and the college graduates more majors in chemistry, physics, and mathematics than any other higher education institution on the island.

The Council for Higher Education Accreditation gave the CUH its autonomy permitting the designation of the first rector (chancellor) and directive bodies.

Nowadays, the UPRH is accredited by the Middle States Commission on Higher Education and offers over 26 undergraduate programs, including 5 associate degrees.

[5] The Fall 2016 Freshman class of approximately 990 students earned admission to the university campus with an average SAT score of 1458 – 1809 (out of 2400).

To meet the demand for labor in that region UPRH offers unique baccalaureate programs in the UPR system and Puerto Rico in: Also, other unique major programs that UPRH offers are: This campus has been the scene of the Dove Project Sabanera, native species threatened with extinction, Project Moonbuggy for designing lunar vehicles, and maintains the Microbial Observatory of the Salinas in Cabo Rojo sponsored by the National Science Foundation.

[8] In April 2017, the UPR Humacao team won the first place in the university category during the fourth competition of NASA Human Exploration Rover Challenge which was held at the U.S. Space & Rocket Center in Huntsville, Alabama.

UPRH faculty continue to be recognized on the academic stage constantly by many national agencies and associations as the Dictionary of Caribbean and Afro-Latin American Biography, the Partnership for Research and Education in Materials, National Science Foundation, Annual Biomedical Research Conference for Minority Students, the Puerto Rico Board of Accountacy, and the Emeritus Professor award.

Research conducted through the collaboration will focus on two nanotechnology-related topics: multi-functional nanodevices from optoelectronic materials and nanoscale interactions of macromolecules at soft and hard interfaces.

[12] The UPRH is part of the Space-Grant Consortium by NASA that is focused in the research, education, and workforce development of Puerto Rico in Science, Technology, Engineering, and Mathematics.

[13] Also, UPR Humacao have the Sea-Grant program dedicated to the scientific research in marine and coastal resources, and its conservation in Puerto Rico and the Caribbean region.

The observatory also serves the Astronomical Society of Puerto Rico, school teachers, science fair students, radio and television stations.

The UPR Humacao Astronomical Observatory is open to the entire University community and general public in the island free of any charges on most Thursday nights and the talks can be in Spanish, English or both (depending on the audience), always welcoming questions during the presentation.

[16] UPRH stimulates literary, musical and theatrical creation in the university community, through various events to present the art-works, such as contests, festivals and recitals.

Also, provides the opportunity to the talent of the university community through the creation of projects, exhibitions and presentations that serve as artistic experiences that reinforce their learning process in our Institution.

There are a wide variety of registered student organizations at UPRH, including academic, professional, special interest, and multicultural groups.