The University of Strasbourg is currently composed of 35 academic faculties, schools and institutes, plus 71 research laboratories spread over six campuses, including the historic site in the Neustadt.

Among its earliest university students was Johann Scheffler who studied medicine and later converted to Catholicism and became the mystic and poet Angelus Silesius.

The university was refounded as the German Kaiser-Wilhelm-Universität in 1872, after the Franco-Prussian war and the annexation of Alsace-Lorraine to Germany provoked a westwards exodus of Francophone teachers.

[5] The university campus covers a vast part near the center of the city, located between the "Cité Administrative", "Esplanade" and "Gallia" bus-tram stations.

Modern architectural buildings include: Escarpe, the Doctoral College of Strasbourg, Supramolecular Science and Engineering Institute (ISIS), Atrium, Pangloss, PEGE (Pôle européen de gestion et d'économie) and others.