The University of Strasbourg is currently composed of 35 academic faculties, schools and institutes, plus 71 research laboratories spread over six campuses, including the historic site in the Neustadt.

The university emerged from a Lutheran humanist German Gymnasium, founded in 1538 by Johannes Sturm in the Free Imperial City of Strassburg.

The university was refounded as the German Kaiser-Wilhelm-Universität in 1872, after the Franco-Prussian war and the annexation of Alsace-Lorraine to Germany provoked a westwards exodus of Francophone teachers.

[5] The university campus covers a vast part near the center of the city, located between the "Cité Administrative", "Esplanade" and "Gallia" bus-tram stations.

Modern architectural buildings include: Escarpe, the Doctoral College of Strasbourg, Supramolecular Science and Engineering Institute (ISIS), Atrium, Pangloss, PEGE (Pôle européen de gestion et d'économie) and others.