"[3] In 1988, the singer/guitarist Chris Spencer, bass guitarist Pete Shore and drummer Charlie Ondras were students at Sarah Lawrence College when they formed Lawn-Chair-Blisters[4] before changing the name to Unsane.

[4][5] Unsane became part of the scene of loud, noisy, like-minded rock groups in New York City's East Village in the early 1990s.

The band's first album, Unsane, was released in 1991,[6] and was known for its harsh music and gruesome cover art with a photo of a decapitated man on a New York subway track wearing a Members Only jacket.

In 2019, Spencer announced the formation of a new band, Human Impact, with ex-Swans members Phil Puleo and Chris Pravdica.

Spencer subsequently announced his departure from Unsane in August 2019, first in an interview about Human Impact with the Italian-language music zine Equilibrio Precario, and then in English in a comment on a Facebook post of the same article.

Curran formed J.J. Paradise Players Club and Signorelli opened a tattoo shop in Middle Village Queens.

In 2008 Spencer formed the band Celan with Ari Benjamin Meyers (Redux Orchestra), Niko Wenner (Oxbow), Roeder and Xavi (both ex-flu-ID) and, in 2009, they released the well-reviewed album Halo on the Berlin label Exile on Mainstream Records and toured Europe.

In 2015 Spencer formed UXO with Steve Austin of Today is the Day, Aarne Victorine, and Pat Kennedy.