The Up in Smoke Tour was a West Coast hip hop tour in 2000 which was headlined by Dr. Dre and Snoop Dogg, also featuring artists and disc jockeys Ice Cube, Eminem, Proof, Nate Dogg, Kurupt, D12, MC Ren, Westside Connection, Chilldrin of da Ghetto, Mel-Man, Tha Eastsidaz, Doggy's Angels, Devin The Dude, Warren G, Crucial Conflict, TQ, Truth Hurts, Xzibit, The D.O.C., Hittman, DJ Crazy Toones, Six-Two, Ms. Toi, & DJ Jam.

MC Ren, one of the former members of N.W.A, was expected to join the tour in order to have reunited version of N.W.A along with Dr. Dre, Ice Cube, and Snoop Dogg.

Dr. Dre and Snoop Dogg would be the final set with collaborations including the N.W.A reunion taking place during this segment.

appeared on stage with Dre and Snoop Dogg on July 20, 2000 at The Centrum in Worcester, Massachusetts, when they performed the intro to "Let Me Ride" and "Still D.R.E.".

[7] In October 2009, Aftermath Entertainment artist Bishop Lamont said to expect another Up in Smoke Tour when Dr. Dre's studio album, Detox was released.