It is endemic to Sri Lanka and is known from the Central, Sabaragamuwa, Southern, and Western Provinces.

The toes have rudimentary webbing and slightly truncate or rounded, enlarged, fleshy and smooth tips.

Reddish-orange patches are present on the snout, sides of the dorsum, abdomen, and around the vent and on the limbs.

[2] Uperodon nagaoi are terrestrial and arboreal as adults and prefer lowland moist forest habitats.

One female was found submerged in a tree hole, with an egg clutch adhering to the wall few centimeters above the water level.