Upington (Khoekhoe: ǁKhara hais) is a town founded in 1873 and located in the Northern Cape province of South Africa, on the banks of the Orange River.

The museum is also the home of a donkey statue, which recognises the enormous contribution that this animal made to the development of the region during the pioneering days of the 19th century.

It is the closest large centre to the Augrabies Falls (arguably the greatest of South African waterfalls) and the Kgalagadi Transfrontier Park.

The area is best known for its export-quality grapes, raisins and wines, which are cultivated on the rich flood plains of the Orange River.

The organisation has six depots in the area (all of them on the banks of the Orange River) at Upington, Kanoneiland, Grootdrink, Kakamas, Keimoes and Groblershoop.

Until the 1950s, a narrow-gauge railway line (two-foot gauge) ran from Upington to Kakamas and Keimoes, two nearby towns.