[2] James Fisher was the vicar at Sheffield Parish Church during the Commonwealth of England.

He was expelled in the Great Ejection for refusing to sign the Act of Uniformity 1662, and around a tenth of his parishioners followed him in becoming Dissenters.

The chapel originally boasted a congregation of about 1,000 people, a sixth of the city's population.

The alterations by John Frith were completed in 1848, while the interior has several later additions, including several stained glass windows.

[2] Nineteenth-century ministers included George Vance Smith, Brooke Herford, Thomas Hinks and John Edmondson Manning, who wrote a history of the chapel in 1900.