[3][4] Although most Hispanics in the neighborhood are Mexicans, there are significant populations of Salvadorans, Puerto Ricans, Hondurans, Dominicans, Guatemalans, Colombians, and Cubans, as well as many others.

It is bordered by S. Broadway on the west, S. Patterson Park Avenue on the east, E. Lombard Street on the north and Eastern Avenue on the south, Upper Fells Point's central location puts residents within walking distance of Patterson Park, the dining and nightlife of Fells Point, Little Italy and Canton, and Johns Hopkins Hospital.

The river offered a deep-water anchorage, which enabled seagoing vessels to send smaller boats back and forth from shore with cargo.

Czechs from Bohemia, Scandinavians, Italians, and Poles found work and lodging in Upper Fells Point.

Adding to the neighborhood's ethnic diversity are Hispanic immigrants who began to arrive in the 1960s and 1970s and Lumbee Native Americans who migrated from the Carolinas.