Jim Breuer and Rob Magnotti were the only regular white cast members.

Uptown Comedy Club would in hindsight, provide a springboard for future Saturday Night Live cast members Jim Breuer and Tracy Morgan and future Mad TV cast members Aries Spears and Debra Wilson.

Monteria Ivey[12][13] served as the host for the first season, while the regular cast members rotated in that capacity for the second.

A recurring segment on Uptown Comedy Club was pitting stand-up comedians against each other in a game of The Dozens.

Uptown Comedy Club aired mostly late at night on UHF[33] stations.