[1] He studied in the class of professor Christian Griepenkerl, who also taught Predić's contemporary Paja Jovanović.

During that time, under the instruction of professor Grieppenkerl, and the architect Theophil Freiherr von Hansen, he painted 13 wall paintings of ancient, historical and mythological compositions for the frieze in the House of Lords at the Reichsratsgebäude (Imperial Council Building) in Vienna.

He was one of the founders of the "Lada" society in 1904 (alongside Beta Vukanović, Marko Murat, Đorđe Jovanović, Simeon Roksandić),[2] and became its president.

Uroš Predić's studio, where he painted his most valuable works in the period of 1909-1953, is located at 27 Svetogorska Street in Belgrade.

[5] Some of his famous works include Merry brothers, Orphan (on mother's grave), the historical painting Bosnia-Herzegovinian fugitives and perhaps his most recognizable Kosovo Maiden.

He also painted portraits of Michael I. Pupin, Laza Kostić, Mihailo Petrović Alas (1943), Ksenija Atanasijević (1917), Branislav Petronijević (1911) amongst others.