[2] After the basic, first-year course in art and design, he enrolled in the school's photography department, and supported himself by working as a bouncer at Zurich night clubs and house parties.

The artist employs a variety of materials and processes in his work,[4] including novel computation systems and artificial intelligence,[5] resulting in an oeuvre that “resists easy classification”.

[1] Fischer has been described by the arts and culture magazine Vault as “internationally celebrated” and one of the most significant contemporary artists working today,[8] with global sale prices reaching up to $6.8 million.

[4] In Death of a Moment (2007), two entire walls are equipped with floor-to-ceiling mirrors and set in motion by a hydraulic system, to create the surreal effect of a room in flux, morphing in shape and size.

Giambologna's original work in the Piazza della Signoria was digitized using an optical scanner, and the image was used to create a 3D model in polyurethane foam.

In 2012, Fischer exhibited his first show at Gagosian, “Beds & Problem Paintings”, featuring oversized vintage Hollywood publicity stills obstructed by silkscreened images of mundane objects.

- The New York Times Magazine[16] In 2012, Fischer launched his own publishing imprint, Kiito-San, whose books are distributed by DAP[17] and Buchhandlung Walther König.

[22] While being locked down in Los Angeles during the COVID pandemic, Fischer created a new series of paintings inspired by home life (including his house, garden, studio, and childhood photographs), The Intelligence of Nature, that was exhibited at Sadie Coles HQ in 2021.

[24] In 2021, he fully explored digital sculpture for this first time with CHAOS, a series containing 1000 digitally-scanned and recreated everyday physical objects (like an egg and a lighter) paired to interact with each other.

Released as a series of 500 individual NFTs and culminating in a capstone piece, CHAOS #501, the project took over two years to complete and involved a global team of experts in 3D modeling, animation, and motion capture.

[27] In September 2022, CHAOS #501, the culmination of the series, was exhibited in the show "Denominator" at Gagosian in New York City on a state-of-the-art 14’ x 30’ micro LED wall display with .84 pixel pitch.

At the same show, Fischer unveiled two new pieces: People, a recreation of Room 43 of the National Gallery featuring replicas of paintings from artists like Van Gogh, with clips of cutout heads of YouTube video influencers projected over it.

For his 2007 show at Gavin Brown's Enterprise in New York, Fischer excavated the gallery's main room, bringing in contractors to dig an eight-foot hole where the floor had been, and calling the result You.

Today, his wax sculptures are refined portraits of significant art world figures that are lit like candles and melted over the duration of an exhibition.

The wax works are almost exclusively sculptural portraits of human subjects, and the process of melting lends itself to contemplation of existentialism and the ultimate meaning of art and its legacy.

[6] The melting wax and fruit and vegetables in the fridge are a reference to memento mori of seventeenth-century Dutch painting, where motifs such as food, candles, hourglasses and skulls are utilised as a reminder of mortality.

[37] In another interview with the Canberra Times, Mitzevich says that the sculpture demonstrates that contemporary art “is not static, it is alive and always changing, reflecting the world in which we live”.

This included curation of Fischer’s own works as well as physical interventions in the space such as You 2007, where the artist has cut huge holes out of the museum wall, and an interactive piece Yes 2013 that consisted of many ‘sculptural experiments’ in clay created by visitors to the exhibition.

[48] Recent major exhibitions include "Not My House Not My Fire," Espace 315, Centre Pompidou, Paris (2004); "Mary Poppins," Blaffer Gallery, Art Museum of the University of Houston, Houston, Texas (2006); "Urs Fischer: Marguerite de Ponty," New Museum of Contemporary Art, New York (2009–10);[49] "Skinny Sunrise", Kunsthalle Wien, Vienna (2012);[50] "Madame Fisscher," Palazzo Grassi, Venice (2012); "Urs Fischer," Museum of Contemporary Art, Los Angeles (2013); and "YES," Deste Foundation Project Space, Hydra, Greece (2013);[51] “Play,” Gagosian West 21st Street, New York, 2018, “Maybe,” The Modern Institute, Glasgow (2018); “Dasha,” Gagosian, Davies Street, London (2018); “Big Clay #4 and 2 Tuscan Men,” Piazza della Signoria, Florence (2017); “The Public & the Private,” Legion of Honour Museum, San Francisco (2017); “SIRENS,” Galerie Max Hetzler (2019); and “Images,” Gagosian, Beverly Hills (2019).

[53][54] New candle works created for the exhibition features artists Spencer Sweeney, Kembra Pfahler, art dealer Esthella Provas, and founder Eugenio López Alonso.