The avenue was inaugurated by Leguía at the main square of Bellavista District on December 10, 1924, as part of the programme of the commemoration of the Battle of Ayacucho.

Leguía again took part in the ceremony, accompanied by Mayors Luis T. Larco of Lima and Enrique de las Casas of Barranco, as well as Intendant of Callao, Eduardo Fry.

[3] The first block of Uruguay Avenue houses the former La Recoleta and Belén schools, both operated by the Congregation of the Sacred Hearts of Jesus and Mary and opened in the mid-19th century.

[3] Thanks to its protected status due to its administration by the French colony in the city, the Colegio Belén served as a refuge for Peruvians during the occupation of Lima, and later had singer-songwriter Chabuca Granda among its alumni.

Near the building was the Edificio Ferrand, also by the same architect, which was where one of the first Ford del Perú S.A. stores in the country was opened, and also served as the residence of the German consul and delegation before relations were severed due to World War II.