In a career spanning about 10 years, she has established herself as one of the leading playback singers in the Telugu film industry and has worked with many major music directors.

Usha began her singing career with "Paadutha Teeyaga", a music based program on Eenadu Television hosted by singer S. P. Balasubrahmanyam.

She later participated in "Meri Awaz Suno" on Star TV and was one of the finalists in the All-India finals.

She sang in various Telugu movies like Indra, Chiruta, Athidhi, Pourudu, Varsham, Bhadra, Chitram, Nuvvu Nenu, Manasantha Nuvve, Nuvvu Leka Nenu Lenu, Jayam, Santhosham, Nee Sneham, Avunanna Kadanna and many more.

Usha has recorded with music directors, such as Ilaiyaraaja, M. M. Keeravani, Koti, Mani Sharma, Vandemataram Srinivas, Devi Sri Prasad, Kamalakar, RP Patnaik, Chakri, Yuvan Shankar Raja, Ramana Gogula and others.