Usolye-Sibirskoye (Russian: Усолье-Сибирское, IPA: [ʊˈsolʲjə sʲɪˈbʲirskəjə]) is a town in Irkutsk Oblast, Russia, located on the left bank of the Angara River.

[3] Until November 2016, Usolye-Sibirskoye served as the administrative center of Usolsky District,[11][12] even though it was not a part of it.

With the opening of a major mine in 1956, the town became Russia's largest producer of table salt.

There is also assembly plant for heavy machinery, including mining equipment produced by the company Usolyemash.

The town has a station on the Trans-Siberian Railway, and is located on the highway from Novosibirsk to Irkutsk.