[2] It came into being after the upgrade of UP Rural Institute of Medical Sciences and Research (established in 2005) by Government of Uttar Pradesh under Act 15 of 2016.

Rural Institute of Medical Sciences and Research, a state government run medical college affiliated with Chhatrapati Shahu Ji Maharaj University, Kanpur was established in Saifai village, District Etawah, Uttar Pradesh.

In February 2015, Government of Uttar Pradesh started the process of establishing a university of medical sciences in Saifai, Etawah by upgrading existing U.P.

On 4 February 2015, the state assembly passed a bill named "Uttar Pradesh University of Medical Sciences, Saifai, Etawah Bill-2015".

[12] It is also one of two Para Medical colleges to get the highest rating of 'A' by the ranking system of the Uttar Pradesh government.

[14][15][16] 300 bedded Obstetrics & Gynaecology and Paediatrics hospital is being established in the university by Government of Uttar Pradesh at a cost of 750 ₹ crores which will be spread across 50 acres of land.