Uzbekistan sent a delegation to compete at the 2010 Winter Olympics in Vancouver, British Columbia, Canada, from 12–28 February 2010.

The delegation consisted of three athletes: Kseniya Grigoreva and Oleg Shamaev in alpine skiing, and Anastasia Gimazetdinova in figure skating.

[3] The only Uzbekistani Winter Olympics medal was won by Lina Cheryazova, a freestyle skier, in 1994 in Lillehammer, Norway.

[3] The delegation sent to Vancouver in 2010 consisted of three competitors; two alpine skiers, Kseniya Grigoreva and Oleg Shamaev, and one figure skater, Anastasia Gimazetdinova.

[20] In Vancouver, she scored a 49.02 for her short program, which put her in 24th place, the last position to qualify for the free skate.