Perinuclear vacuolization of epidermal keratinocytes is most likely inconsequential when not observed in combination with other pathologic findings.
In dermatopathology "vacuolization" often refers specifically to vacuoles in the basal cell-basement membrane zone area, where it is an unspecific sign of disease.
[1] It may be a sign of for example vacuolar interface dermatitis, which in turn has many causes.
It is one of the components of koilocytosis, which may be present in potentially pre-cancerous cervical, oral and anal lesions.
This dermatology article is a stub.