[3][4] Lisitsa independently launched her career on social media, without initially signing with a tour promoter or record company.

[5][6] The Toronto Symphony canceled her 2015 engagements as a soloist with them because of her social media postings in support of pro-Russian separatists during the Russo-Ukrainian War.

[7][10] Lisitsa attended the Lysenko music school and, later, the Kyiv Conservatory,[11] where she and her future husband, Alexei Kuznetsoff, studied under Dr. Ludmilla Tsvierko.

[15][16] In 2010, Lisitsa told an interviewer, she and her husband put their life savings into recording a CD of Rachmaninoff concertos with the London Symphony Orchestra, in hopes of furthering her career.

[8] Lisitsa performed in front of the former Ukrainian Embassy in Moscow on 2 May 2022, to commemorate victims of the 2014 Trade Unions House fire.

[7][20] In 2022, Benjamin Ivry wrote in International Piano Magazine that Lisitsa had "parrot[ted] Putin’s propagandistic talking points about Ukraine".

[28] Her recording of the four sonatas for violin and piano by composer Charles Ives, made with Hilary Hahn, was released in October 2011 on Deutsche Grammophon label.

Her album Valentina Lisitsa Live at the Royal Albert Hall (based on her debut performance at that venue 19 June 2012) was released 2 July 2012.