The Valentine Wilson House was a historic residence in Madison County, Ohio, United States.

[2] Born in Harpers Ferry, Virginia in 1785, he moved with his family to Kentucky in 1790 and to Ohio in 1802; they settled in Greene County, where he married the former Eleanor Judy in 1806.

[3] In 1816, the Wilson family moved to Madison County and purchased land along the trail that later became the National Road; here, Valentine quickly became a prosperous farmer.

Into the late twentieth century, it remained little unchanged and retained the sense of an elaborate early nineteenth-century farmhouse far more strongly than many slightly later residences, which generally were erected with heavy vernacular influences.

[2] It was the first place in Madison County to be accorded this distinction,[1] but designation as a historic site has not succeeded in ensuring its survival: the house has since been destroyed.