Valerio Lorenzo de los Santos (born October 6, 1972) is a Dominican former professional baseball pitcher.

De los Santos was originally signed by the Milwaukee Brewers as an amateur free agent in 1993.

On September 2, 2003, the Brewers traded De los Santos to the Philadelphia Phillies in exchange for cash considerations.

De los Santos pitched to a 9.00 ERA over 6 games for the Phillies in 2003 and elected free agency on December 21, 2003.

De los Santos signed a minor league deal with the Washington Nationals.

On June 13, 2006, De los Santos signed a minor league deal with the Chicago White Sox.

On February 17, 2008, De los Santos signed a minor league deal with the Colorado Rockies.

Shortly after his release from the Mets, De los Santos signed with the Uni-President 7-Eleven Lions of the Chinese Professional Baseball League.